New proapoptotic chemotherapeutic agents based on the quinolone-3-carboxamide scaffold acting by VEGFR-2 inhibition

In the current study, we designed and synthesized a series of new quinoline derivatives 10a-p as antiproliferative agents targeting cancer through inhibition of VEGFR-2. Preliminary molecular docking to assess the interactions of the designed derivatives with the binding site of VEGFR-2 (PDB code: 4...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Fakharany, Zeinab S., Nissan, Yassin M., Sedky, Nada K., Arafa, Reem K., Abou-Seri, Sahar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444817/
https://www.ncbi.nlm.nih.gov/pubmed/37443185
http://dx.doi.org/10.1038/s41598-023-38264-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444817/
https://www.ncbi.nlm.nih.gov/pubmed/37443185
http://dx.doi.org/10.1038/s41598-023-38264-w

Ejemplares similares