Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming

M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) activity. Here, we provide evidence that NO targets the PDH complex by using lipoate to generate nitroxyl (HNO). PDH E2-associated li...

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Detalles Bibliográficos
Autores principales: Palmieri, Erika M., Holewinski, Ronald, McGinity, Christopher L., Pierri, Ciro L., Maio, Nunziata, Weiss, Jonathan M., Tragni, Vincenzo, Miranda, Katrina M., Rouault, Tracey A., Andresson, Thorkell, Wink, David A., McVicar, Daniel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444860/
https://www.ncbi.nlm.nih.gov/pubmed/37607904
http://dx.doi.org/10.1038/s41467-023-40738-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444860/
https://www.ncbi.nlm.nih.gov/pubmed/37607904
http://dx.doi.org/10.1038/s41467-023-40738-4

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