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Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming
M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) activity. Here, we provide evidence that NO targets the PDH complex by using lipoate to generate nitroxyl (HNO). PDH E2-associated li...
Autores principales: | Palmieri, Erika M., Holewinski, Ronald, McGinity, Christopher L., Pierri, Ciro L., Maio, Nunziata, Weiss, Jonathan M., Tragni, Vincenzo, Miranda, Katrina M., Rouault, Tracey A., Andresson, Thorkell, Wink, David A., McVicar, Daniel W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444860/ https://www.ncbi.nlm.nih.gov/pubmed/37607904 http://dx.doi.org/10.1038/s41467-023-40738-4 |
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