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α-parvin controls chondrocyte column formation and regulates long bone development

Endochondral ossification requires proper control of chondrocyte proliferation, differentiation, survival, and organization. Here we show that knockout of α-parvin, an integrin-associated focal adhesion protein, from murine limbs causes defects in endochondral ossification and dwarfism. The mutant l...

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Detalles Bibliográficos
Autores principales: Yuan, Jifan, Guo, Ling, Wang, Jiaxin, Zhou, Zhongjun, Wu, Chuanyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444880/
https://www.ncbi.nlm.nih.gov/pubmed/37607905
http://dx.doi.org/10.1038/s41413-023-00284-7