Cargando…
Non-terminal conjugation of small interfering RNAs with spermine improves duplex binding and serum stability with position-specific incorporation
The conjugation of small interfering RNAs (siRNAs) has been studied using lipid and ligand conjugates for efficient delivery. However, most conjugates have been inserted at the terminal position; very few have been inserted at non-terminal positions. Herein, we synthesized a 4′-C-propyllevulinate-2′...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445083/ https://www.ncbi.nlm.nih.gov/pubmed/37622021 http://dx.doi.org/10.1039/d3ra04918c |