Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice

BACKGROUND: The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been described in both immune cells and platelets, but its role in the megakaryocyte (MK) lineage remains elusive. OBJECTIVE: The aim of this study was to explore the role of NLRP3 inflammasome in megakaryocyt...

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Detalles Bibliográficos
Autores principales: Bourne, Joshua H., Campos, Joana, Hopkin, Sophie J., Whitworth, Katharine, Palis, James, Senis, Yotis A., Rayes, Julie, Iqbal, Asif J., Brill, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445124/
https://www.ncbi.nlm.nih.gov/pubmed/37622117
http://dx.doi.org/10.3389/fimmu.2023.1226196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445124/
https://www.ncbi.nlm.nih.gov/pubmed/37622117
http://dx.doi.org/10.3389/fimmu.2023.1226196

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