TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients

INTRODUCTION: TDP-43 proteinopathy in Alzheimer’s disease (AD) patients is recently emerging as a relevant pathomolecular event that may have been overlooked. Recent results in immortalized lymphocytes from AD patients have shown not only an increase of post-translational modifications in TDP-43, su...

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Detalles Bibliográficos
Autores principales: Martinez-Gonzalez, Loreto, Cuevas, Eva P., Tosat-Bitrián, Carlota, Nozal, Vanesa, Gil, Carmen, Palomo, Valle, Martín-Requero, Ángeles, Martinez, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445132/
https://www.ncbi.nlm.nih.gov/pubmed/37621404
http://dx.doi.org/10.3389/fnmol.2023.1243277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445132/
https://www.ncbi.nlm.nih.gov/pubmed/37621404
http://dx.doi.org/10.3389/fnmol.2023.1243277

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