A Case of a Coexisting Carcinosarcoma Ex Pleomorphic Adenoma With Langerhans Cell Histiocytosis in the Parotid Gland

Carcinosarcoma ex pleomorphic adenoma is a rare malignant neoplasm, with most cases reported in the parotid gland. We herein report a case of a 75-year-old male referred to our hospital with a long-standing right parotid lesion that was treated in an outside hospital by a superficial parotidectomy....

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Autores principales: AlMadan, Nasser M, Sulaiman, Shatha M, Almayouf, Furat, Alwhabi, Mohammed, Alquwayz, Turki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445182/
https://www.ncbi.nlm.nih.gov/pubmed/37621779
http://dx.doi.org/10.7759/cureus.42351
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author AlMadan, Nasser M
Sulaiman, Shatha M
Almayouf, Furat
Alwhabi, Mohammed
Alquwayz, Turki
author_facet AlMadan, Nasser M
Sulaiman, Shatha M
Almayouf, Furat
Alwhabi, Mohammed
Alquwayz, Turki
author_sort AlMadan, Nasser M
collection PubMed
description Carcinosarcoma ex pleomorphic adenoma is a rare malignant neoplasm, with most cases reported in the parotid gland. We herein report a case of a 75-year-old male referred to our hospital with a long-standing right parotid lesion that was treated in an outside hospital by a superficial parotidectomy. The patient reported a painful, rapidly enlarging mass following the excision. Histopathological examination showed the proliferation of malignant epithelial and mesenchymal elements with a solid sheet of Langerhans cells admixed with eosinophils. The Langerhans cells were reactive to CD1a and BRAF; hence, a diagnosis of carcinosarcoma ex pleomorphic adenoma with Langerhans cell histiocytosis was given. Complete clinical and radiographic workup showed no other organ involvement. The patient underwent total parotidectomy with adjuvant chemoradiation; however, the tumor progressed and showed lung metastasis. We herein report the first case of a concurrent Langerhans cell histiocytosis with associated carcinosarcoma ex pleomorphic adenoma.
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spelling pubmed-104451822023-08-24 A Case of a Coexisting Carcinosarcoma Ex Pleomorphic Adenoma With Langerhans Cell Histiocytosis in the Parotid Gland AlMadan, Nasser M Sulaiman, Shatha M Almayouf, Furat Alwhabi, Mohammed Alquwayz, Turki Cureus Pathology Carcinosarcoma ex pleomorphic adenoma is a rare malignant neoplasm, with most cases reported in the parotid gland. We herein report a case of a 75-year-old male referred to our hospital with a long-standing right parotid lesion that was treated in an outside hospital by a superficial parotidectomy. The patient reported a painful, rapidly enlarging mass following the excision. Histopathological examination showed the proliferation of malignant epithelial and mesenchymal elements with a solid sheet of Langerhans cells admixed with eosinophils. The Langerhans cells were reactive to CD1a and BRAF; hence, a diagnosis of carcinosarcoma ex pleomorphic adenoma with Langerhans cell histiocytosis was given. Complete clinical and radiographic workup showed no other organ involvement. The patient underwent total parotidectomy with adjuvant chemoradiation; however, the tumor progressed and showed lung metastasis. We herein report the first case of a concurrent Langerhans cell histiocytosis with associated carcinosarcoma ex pleomorphic adenoma. Cureus 2023-07-24 /pmc/articles/PMC10445182/ /pubmed/37621779 http://dx.doi.org/10.7759/cureus.42351 Text en Copyright © 2023, AlMadan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
AlMadan, Nasser M
Sulaiman, Shatha M
Almayouf, Furat
Alwhabi, Mohammed
Alquwayz, Turki
A Case of a Coexisting Carcinosarcoma Ex Pleomorphic Adenoma With Langerhans Cell Histiocytosis in the Parotid Gland
title A Case of a Coexisting Carcinosarcoma Ex Pleomorphic Adenoma With Langerhans Cell Histiocytosis in the Parotid Gland
title_full A Case of a Coexisting Carcinosarcoma Ex Pleomorphic Adenoma With Langerhans Cell Histiocytosis in the Parotid Gland
title_fullStr A Case of a Coexisting Carcinosarcoma Ex Pleomorphic Adenoma With Langerhans Cell Histiocytosis in the Parotid Gland
title_full_unstemmed A Case of a Coexisting Carcinosarcoma Ex Pleomorphic Adenoma With Langerhans Cell Histiocytosis in the Parotid Gland
title_short A Case of a Coexisting Carcinosarcoma Ex Pleomorphic Adenoma With Langerhans Cell Histiocytosis in the Parotid Gland
title_sort case of a coexisting carcinosarcoma ex pleomorphic adenoma with langerhans cell histiocytosis in the parotid gland
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445182/
https://www.ncbi.nlm.nih.gov/pubmed/37621779
http://dx.doi.org/10.7759/cureus.42351
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