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Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon‐derived peptides

AIMS/INTRODUCTION: Glucagon is secreted from pancreatic α‐cells and plays an important role in amino acid metabolism in liver. Various animal models deficient in glucagon action show hyper‐amino acidemia and α‐cell hyperplasia, indicating that glucagon contributes to feedback regulation between the...

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Detalles Bibliográficos
Autores principales: Ueno, Shinji, Seino, Yusuke, Hidaka, Shihomi, Nakatani, Masashi, Hitachi, Keisuke, Murao, Naoya, Maeda, Yasuhiro, Fujisawa, Haruki, Shibata, Megumi, Takayanagi, Takeshi, Iizuka, Katsumi, Yabe, Daisuke, Sugimura, Yoshihisa, Tsuchida, Kunihiro, Hayashi, Yoshitaka, Suzuki, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445200/
https://www.ncbi.nlm.nih.gov/pubmed/37300240
http://dx.doi.org/10.1111/jdi.14032