Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-Null, and CYP2A6-Humanized Mice

[Image: see text] Polychlorinated biphenyls (PCBs) are environmental contaminants that can cause neurotoxicity. PCBs, such as PCB 95 (2,2′,3,5′,6-pentachlorobiphenyl), can be metabolized by cytochrome P450 enzymes into neurotoxic metabolites. To better understand how the metabolism of PCB 95 affects...

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Detalles Bibliográficos
Autores principales: Li, Xueshu, Bullert, Amanda J., Han, Weiguo, Yang, Weizhu, Zhang, Qing-Yu, Ding, Xinxin, Lehmler, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445290/
https://www.ncbi.nlm.nih.gov/pubmed/37467352
http://dx.doi.org/10.1021/acs.chemrestox.3c00128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445290/
https://www.ncbi.nlm.nih.gov/pubmed/37467352
http://dx.doi.org/10.1021/acs.chemrestox.3c00128

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