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Id-neoantigen vaccine induces therapeutic CD8(+) T cells against multiple myeloma: H chain-loss escapees cause FLC MM
BACKGROUND: Multiple myeloma (MM) cancers originate from plasma cells that have passed through the germinal center reaction where somatic hypermutation of Ig V regions takes place. Myeloma protein V regions often express many mutations and are thus a rich source of neoantigens (traditionally called...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445383/ https://www.ncbi.nlm.nih.gov/pubmed/37607769 http://dx.doi.org/10.1136/jitc-2023-006944 |