Id-neoantigen vaccine induces therapeutic CD8(+) T cells against multiple myeloma: H chain-loss escapees cause FLC MM

BACKGROUND: Multiple myeloma (MM) cancers originate from plasma cells that have passed through the germinal center reaction where somatic hypermutation of Ig V regions takes place. Myeloma protein V regions often express many mutations and are thus a rich source of neoantigens (traditionally called...

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Detalles Bibliográficos
Autores principales: Westhrin, Marita, Blazevski, Jana, Textor, Ana, Abdollahi, Pegah, Gopalakrishnan, Ramakrishna Prabhu, Ngo, Linda Thuy, Hofgaard, Peter Olaf, Heinzelbecker, Julia, Bobic, Sonja, Fossum, Even, Spång, Heidi Cecilie Larsen, Braathen, Ranveig, Bogen, Bjarne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445383/
https://www.ncbi.nlm.nih.gov/pubmed/37607769
http://dx.doi.org/10.1136/jitc-2023-006944

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