LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function

Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation. However, some tumors undergo cellular reprogramming to a more lethal subset termed n...

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Detalles Bibliográficos
Autores principales: Kumaraswamy, Anbarasu, Duan, Zhi, Flores, Diana, Zhang, Chao, Sehrawat, Archana, Hu, Ya-Mei, Swaim, Olivia A., Rodansky, Eva, Storck, William K., Kuleape, Joshua A., Bedi, Karan, Mannan, Rahul, Wang, Xiao-Ming, Udager, Aaron, Ravikumar, Visweswaran, Bankhead, Armand, Coleman, Ilsa, Lee, John K., Morrissey, Colm, Nelson, Peter S., Chinnaiyan, Arul M., Rao, Arvind, Xia, Zheng, Yates, Joel A., Alumkal, Joshi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445684/
https://www.ncbi.nlm.nih.gov/pubmed/37440313
http://dx.doi.org/10.1172/jci.insight.167440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445684/
https://www.ncbi.nlm.nih.gov/pubmed/37440313
http://dx.doi.org/10.1172/jci.insight.167440

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