Delayed skeletal development and IGF-1 deficiency in a mouse model of lysinuric protein intolerance

SLC7A7 deficiency, or lysinuric protein intolerance (LPI), causes loss of function of the y(+)LAT1 transporter critical for efflux of arginine, lysine and ornithine in certain cells. LPI is characterized by urea cycle dysfunction, renal disease, immune dysregulation, growth failure, delayed bone age...

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Detalles Bibliográficos
Autores principales: Stroup, Bridget M., Li, Xiaohui, Ho, Sara, Zhouyao, Haonan, Chen, Yuqing, Ani, Safa, Dawson, Brian, Jin, Zixue, Marom, Ronit, Jiang, Ming-Ming, Lorenzo, Isabel, Rosen, Daniel, Lanza, Denise, Aceves, Nathalie, Koh, Sara, Seavitt, John R., Heaney, Jason D., Lee, Brendan, Burrage, Lindsay C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445726/
https://www.ncbi.nlm.nih.gov/pubmed/37486182
http://dx.doi.org/10.1242/dmm.050118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445726/
https://www.ncbi.nlm.nih.gov/pubmed/37486182
http://dx.doi.org/10.1242/dmm.050118

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