CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease

High-throughput DNA sequencing studies increasingly associate DNA variants with congenital heart disease (CHD). However, functional modeling is a crucial prerequisite for translating genomic data into clinical care. We used CRISPR-Cas9-mediated targeting of 12 candidate genes in the vertebrate model...

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Detalles Bibliográficos
Autores principales: Doering, Lino, Cornean, Alex, Thumberger, Thomas, Benjaminsen, Joergen, Wittbrodt, Beate, Kellner, Tanja, Hammouda, Omar T., Gorenflo, Matthias, Wittbrodt, Joachim, Gierten, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445736/
https://www.ncbi.nlm.nih.gov/pubmed/37584388
http://dx.doi.org/10.1242/dmm.049811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445736/
https://www.ncbi.nlm.nih.gov/pubmed/37584388
http://dx.doi.org/10.1242/dmm.049811

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