Monte Carlo Thompson sampling-guided design for antibody engineering

Antibodies are one of the predominant treatment modalities for various diseases. To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively explored their sequence space. However, it is practically unfe...

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Detalles Bibliográficos
Autores principales: Kakuzaki, Taro, Koga, Hikaru, Takizawa, Shuuki, Metsugi, Shoichi, Shiraiwa, Hirotake, Sampei, Zenjiro, Yoshida, Kenji, Tsunoda, Hiroyuki, Teramoto, Reiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446805/
https://www.ncbi.nlm.nih.gov/pubmed/37605371
http://dx.doi.org/10.1080/19420862.2023.2244214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446805/
https://www.ncbi.nlm.nih.gov/pubmed/37605371
http://dx.doi.org/10.1080/19420862.2023.2244214

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