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In Silico Evaluation of Variant Calling Methods for Bacterial Whole-Genome Sequencing Assays

Identification and analysis of clinically relevant strains of bacteria increasingly relies on whole-genome sequencing. The downstream bioinformatics steps necessary for calling variants from short-read sequences are well-established but seldom validated against haploid genomes. We devised an in sili...

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Detalles Bibliográficos
Autores principales: Seah, Yee Mey, Stewart, Mary K., Hoogestraat, Daniel, Ryder, Molly, Cookson, Brad T., Salipante, Stephen J., Hoffman, Noah G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446864/
https://www.ncbi.nlm.nih.gov/pubmed/37428072
http://dx.doi.org/10.1128/jcm.01842-22