Design, synthesis, and greener pasture biological assessment of a novel nucleoside: 1-(α-D-ribofuranosyl)-6,7-difluoro-2-methyl-4-quinazolinone as an inhibitor of COVID-19 and Alzheimer’s disease

Synthesis of a new fluorinated nucleoside of 6,7-difluoro-2-methyl-4-quinazolinone was described. 2-Amino-4,5-difluorobenzoic acid 1 reacts with (CH(3)CO)(2)O followed by ammonia to form (1H)-6,7-difluoro-2-methyl-4-quinazolinone 3a. Ribosylation of a silylated 4 with l-O-acety1-2,3-5-tri-O-benzoyl-...

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Detalles Bibliográficos
Autores principales: BREAK, Laila M., GOBOURI, Adil A., Al-HSRTHI, Wafa S., HAGAR, Mohamed, Al-KAFF, Nadia S., SAID, Musa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific and Technological Research Council of Turkey (TUBITAK) 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446935/
https://www.ncbi.nlm.nih.gov/pubmed/37621349
http://dx.doi.org/10.55730/1300-0527.3483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446935/
https://www.ncbi.nlm.nih.gov/pubmed/37621349
http://dx.doi.org/10.55730/1300-0527.3483

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