TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP

The abnormal assembly of TAR DNA-binding protein 43 (TDP-43) in neuronal and glial cells characterizes nearly all cases of amyotrophic lateral sclerosis (ALS) and around half of cases of frontotemporal lobar degeneration (FTLD)(1,2). A causal role for TDP-43 assembly in neurodegeneration is evidence...

Descripción completa

Detalles Bibliográficos
Autores principales: Arseni, Diana, Chen, Renren, Murzin, Alexey G., Peak-Chew, Sew Y., Garringer, Holly J., Newell, Kathy L., Kametani, Fuyuki, Robinson, Andrew C., Vidal, Ruben, Ghetti, Bernardino, Hasegawa, Masato, Ryskeldi-Falcon, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447236/
https://www.ncbi.nlm.nih.gov/pubmed/37532939
http://dx.doi.org/10.1038/s41586-023-06405-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447236/
https://www.ncbi.nlm.nih.gov/pubmed/37532939
http://dx.doi.org/10.1038/s41586-023-06405-w

Ejemplares similares