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TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP

The abnormal assembly of TAR DNA-binding protein 43 (TDP-43) in neuronal and glial cells characterizes nearly all cases of amyotrophic lateral sclerosis (ALS) and around half of cases of frontotemporal lobar degeneration (FTLD)(1,2). A causal role for TDP-43 assembly in neurodegeneration is evidence...

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Detalles Bibliográficos
Autores principales:	Arseni, Diana, Chen, Renren, Murzin, Alexey G., Peak-Chew, Sew Y., Garringer, Holly J., Newell, Kathy L., Kametani, Fuyuki, Robinson, Andrew C., Vidal, Ruben, Ghetti, Bernardino, Hasegawa, Masato, Ryskeldi-Falcon, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447236/ https://www.ncbi.nlm.nih.gov/pubmed/37532939 http://dx.doi.org/10.1038/s41586-023-06405-w

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