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TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6
Human tripartite motif protein 5α (TRIM5α) is a well-characterized restriction factor for some RNA viruses, including HIV(1–5); however, reports are limited for DNA viruses(6,7). Here we demonstrate that TRIM5α also restricts orthopoxviruses and, via its SPRY domain, binds to the orthopoxvirus capsi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447239/ https://www.ncbi.nlm.nih.gov/pubmed/37558876 http://dx.doi.org/10.1038/s41586-023-06401-0 |