Germline (epi)genetics reveals high predisposition in females: a 5-year, nationwide, prospective Wilms tumour cohort

BACKGROUND: Studies suggest that Wilms tumours (WT) are caused by underlying genetic (5%–10%) and epigenetic (2%–29%) mechanisms, yet studies covering both aspects are sparse. METHODS: We performed prospective whole-genome sequencing of germline DNA in Danish children diagnosed with WT from 2016 to...

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Detalles Bibliográficos
Autores principales: Stoltze, Ulrik Kristoffer, Hildonen, Mathis, Hansen, Thomas Van Overeem, Foss-Skiftesvik, Jon, Byrjalsen, Anna, Lundsgaard, Malene, Pignata, Laura, Grønskov, Karen, Tumer, Zeynep, Schmiegelow, Kjeld, Brok, Jesper Sune, Wadt, Karin A W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Cancer Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447365/
https://www.ncbi.nlm.nih.gov/pubmed/37019617
http://dx.doi.org/10.1136/jmg-2022-108982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447365/
https://www.ncbi.nlm.nih.gov/pubmed/37019617
http://dx.doi.org/10.1136/jmg-2022-108982

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