Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

Proper regulation of Wnt signaling is critical for normal bone development and homeostasis. Mutations in several Wnt signaling components, which increase the activity of the pathway in the skeleton, cause high bone mass in human subjects and mouse models. Increased bone mass is often accompanied by...

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Detalles Bibliográficos
Autores principales: Diegel, Cassandra R., Kramer, Ina, Moes, Charles, Foxa, Gabrielle E., McDonald, Mitchell J., Madaj, Zachary B., Guth, Sabine, Liu, Jun, Harris, Jennifer L., Kneissel, Michaela, Williams, Bart O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447437/
https://www.ncbi.nlm.nih.gov/pubmed/37612291
http://dx.doi.org/10.1038/s41413-023-00278-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447437/
https://www.ncbi.nlm.nih.gov/pubmed/37612291
http://dx.doi.org/10.1038/s41413-023-00278-5

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