Structural variation cooperates with permissive chromatin to control enhancer hijacking–mediated oncogenic transcription

Structural variants (SVs) involving enhancer hijacking can rewire chromatin topologies to cause oncogene activation in human cancers, including hematologic malignancies; however, because of the lack of tools to assess their effects on gene regulation and chromatin organization, the molecular determi...

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Detalles Bibliográficos
Autores principales: Botten, Giovanni A., Zhang, Yuannyu, Dudnyk, Kseniia, Kim, Yoon Jung, Liu, Xin, Sanders, Jacob T., Imanci, Aygun, Droin, Nathalie, Cao, Hui, Kaphle, Pranita, Dickerson, Kathryn E., Kumar, Kirthi R., Chen, Mingyi, Chen, Weina, Solary, Eric, Ly, Peter, Zhou, Jian, Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447518/
https://www.ncbi.nlm.nih.gov/pubmed/36947815
http://dx.doi.org/10.1182/blood.2022017555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447518/
https://www.ncbi.nlm.nih.gov/pubmed/36947815
http://dx.doi.org/10.1182/blood.2022017555

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