Oncolytic virotherapy with intratumoral injection of vaccinia virus TG6002 and 5-fluorocytosine administration in dogs with malignant tumors

TG6002 is an oncolytic vaccinia virus expressing FCU1 protein, which converts 5-fluorocytosine into 5-fluorouracil. The study objectives were to assess tolerance, viral replication, 5-fluorouracil synthesis, and tumor microenvironment modifications to treatment in dogs with spontaneous malignant tum...

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Detalles Bibliográficos
Autores principales: Béguin, Jérémy, Laloy, Eve, Cochin, Sandrine, Gantzer, Murielle, Farine, Isabelle, Pichon, Christelle, Moreau, Baptiste, Foloppe, Johann, Balloul, Jean-Marc, Machon, Christelle, Guitton, Jérôme, Tierny, Dominique, Klonjkowski, Bernard, Quéméneur, Eric, Maurey, Christelle, Erbs, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448017/
https://www.ncbi.nlm.nih.gov/pubmed/37635744
http://dx.doi.org/10.1016/j.omto.2023.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448017/
https://www.ncbi.nlm.nih.gov/pubmed/37635744
http://dx.doi.org/10.1016/j.omto.2023.07.005

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