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PROTAC targeting cyclophilin A controls virus-induced cytokine storm

Cytokine storms caused by viruses are associated with elevated cytokine levels and uncontrolled inflammatory responses that can lead to acute respiratory distress syndrome. Current antiviral therapies are not sufficient to prevent or treat these complications. Cyclophilin A (CypA) is a key factor th...

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Detalles Bibliográficos
Autores principales: Li, Heqiao, Yang, Wenxian, Li, Huizi, Bai, Xiaoyuan, Zhang, He, Fan, Wenhui, Liu, Wenjun, Sun, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448112/
https://www.ncbi.nlm.nih.gov/pubmed/37636080
http://dx.doi.org/10.1016/j.isci.2023.107535