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Kappa opioid receptor in nucleus accumbens regulates depressive-like behaviors following prolonged morphine withdrawal in mice

Prolonged withdrawal from opioids leads to negative emotions. Kappa opioid receptor (KOR) plays an important role in opioid addiction and affective disorders. However, the underlying mechanism of KOR in withdrawal-related depression is still lacking. We found that escitalopram treatment had a limite...

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Detalles Bibliográficos
Autores principales: Zhang, Jinyu, Lu, Ye, Jia, Min, Bai, Yuying, Sun, Lulu, Dong, Ziqing, Tian, Wenrong, Yin, Fangyuan, Wei, Shuguang, Wang, Yunpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448166/
https://www.ncbi.nlm.nih.gov/pubmed/37636073
http://dx.doi.org/10.1016/j.isci.2023.107536