Cargando…
Photocycle alteration and increased enzymatic activity in genetically modified photoactivated adenylate cyclase OaPAC
Photoactivated adenylate cyclases (PACs) are light activated enzymes that combine blue light sensing capacity with the ability to convert ATP to cAMP and pyrophosphate (PPi) in a light-dependent manner. In most of the known PACs blue light regulation is provided by a blue light sensing domain using...
Autores principales: | Raics, Katalin, Pirisi, Katalin, Zhuang, Bo, Fekete, Zsuzsanna, Kis-Bicskei, Nikolett, Pecsi, Ildiko, Ujfalusi, Kinga Pozsonyi, Telek, Elek, Li, Yin, Collado, Jinnette Tolentino, Tonge, Peter J., Meech, Stephen R., Vos, Marten H., Bodis, Emoke, Lukacs, Andras |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448171/ https://www.ncbi.nlm.nih.gov/pubmed/37468104 http://dx.doi.org/10.1016/j.jbc.2023.105056 |
Ejemplares similares
-
Unraveling the
Photoactivation Mechanism of a Light-Activated
Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural
Amino Acid Mutagenesis
por: Tolentino Collado, Jinnette, et al.
Publicado: (2022) -
Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia
por: Dong, Qian, et al.
Publicado: (2015) -
ATP and AMP Mutually Influence Their Interaction with the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) at Separate Binding Sites
por: Randak, Christoph O., et al.
Publicado: (2013) -
Demonstration of Phosphoryl Group Transfer Indicates That the ATP-binding Cassette (ABC) Transporter Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Exhibits Adenylate Kinase Activity
por: Randak, Christoph O., et al.
Publicado: (2012) -
Functional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy
por: Karadi, Kristof, et al.
Publicado: (2020)