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Deciphering “the language of nature”: A transformer-based language model for deleterious mutations in proteins

Various machine-learning models, including deep neural network models, have already been developed to predict deleteriousness of missense (non-synonymous) mutations. Potential improvements to the current state of the art, however, may still benefit from a fresh look at the biological problem using m...

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Detalles Bibliográficos
Autores principales: Jiang, Theodore T., Fang, Li, Wang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448337/
https://www.ncbi.nlm.nih.gov/pubmed/37636282
http://dx.doi.org/10.1016/j.xinn.2023.100487