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Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages (TAMs) are the principal immune cell infiltrating PDA and are heterogeneous. Here, by employing macrophage fate-mapping approaches and single-c...

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Detalles Bibliográficos
Autores principales: Patterson, Michael T., Burrack, Adam L., Xu, Yingzheng, Hickok, Grant H., Schmiechen, Zoe C., Becker, Samuel, Cruz-Hinojoza, Eduardo, Schrank, Patricia R., Kennedy, Ainsley E., Firulyova, Maria M., Miller, Ebony A., Zaitsev, Konstantin, Williams, Jesse W., Stromnes, Ingunn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448358/
https://www.ncbi.nlm.nih.gov/pubmed/37402168
http://dx.doi.org/10.1016/j.celrep.2023.112732