Integrating Concentration-Dependent Toxicity Data and Toxicokinetics To Inform Hepatotoxicity Response Pathways

[Image: see text] Failure of animal models to predict hepatotoxicity in humans has created a push to develop biological pathway-based alternatives, such as those that use in vitro assays. Public screening programs (e.g., ToxCast/Tox21 programs) have tested thousands of chemicals using in vitro high-...

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Detalles Bibliográficos
Autores principales: Russo, Daniel P., Aleksunes, Lauren M., Goyak, Katy, Qian, Hua, Zhu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448720/
https://www.ncbi.nlm.nih.gov/pubmed/37566783
http://dx.doi.org/10.1021/acs.est.3c02792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448720/
https://www.ncbi.nlm.nih.gov/pubmed/37566783
http://dx.doi.org/10.1021/acs.est.3c02792

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