Productive Germinal Center Responses Depend on the Nature of Stimuli Received by Anti-Insulin B Cells in Type 1 Diabetes–Prone Mice

Islet autoantibodies, including those directed at insulin, predict type 1 diabetes (T1D) in mice and humans and signal immune tolerance breach by B lymphocytes. High-affinity insulin autoantibodies and T follicular helper cell involvement implicate germinal centers (GCs) in T1D. The V(H)125(SD) BCR...

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Detalles Bibliográficos
Autores principales: McNitt, Dudley H., Joosse, Bryan A., Thomas, James W., Bonami, Rachel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2023
Materias:
Adaptive Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448785/
https://www.ncbi.nlm.nih.gov/pubmed/37261716
http://dx.doi.org/10.4049/immunohorizons.2300036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448785/
https://www.ncbi.nlm.nih.gov/pubmed/37261716
http://dx.doi.org/10.4049/immunohorizons.2300036

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