A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors

Methionine aminopeptidase 2 (MetAP2) is essential to endothelial cell growth and proliferation during tumor angiogenesis. M8891 is a novel orally bioavailable, potent, selective, reversible MetAP2 inhibitor with antiangiogenic and antitumor activity in preclinical studies. The safety, tolerability,...

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Detalles Bibliográficos
Autores principales: Carducci, Michael A., Wang, Ding, Habermehl, Christina, Bödding, Matthias, Rohdich, Felix, Lignet, Floriane, Duecker, Klaus, Karpenko, Oleksandr, Pudelko, Linda, Gimmi, Claude, LoRusso, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448909/
https://www.ncbi.nlm.nih.gov/pubmed/37637935
http://dx.doi.org/10.1158/2767-9764.CRC-23-0048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448909/
https://www.ncbi.nlm.nih.gov/pubmed/37637935
http://dx.doi.org/10.1158/2767-9764.CRC-23-0048

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