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Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy
Antibody-cytokine fusions targeted against tumor-associated antigens (TAAs) are promising cancer immunotherapy agents, with many such molecules currently undergoing clinical trials. However, due to the limited number of tumor-specific targets, on-target off-tumor effects can lead to systemic toxicit...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448976/ https://www.ncbi.nlm.nih.gov/pubmed/37608616 http://dx.doi.org/10.1080/19420862.2023.2245111 |