Discovery of novel RARα agonists using pharmacophore-based virtual screening, molecular docking, and molecular dynamics simulation studies

Nuclear retinoic acid receptors (RARs) are ligand-dependent transcription factors involved in various biological processes, such as embryogenesis, cell proliferation, differentiation, reproduction, and apoptosis. These receptors are regulated by retinoids, i.e., retinoic acid (RA) and its analogs, a...

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Detalles Bibliográficos
Autores principales: Ghorayshian, Atefeh, Danesh, Mahshid, Mostashari-Rad, Tahereh, fassihi, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449137/
https://www.ncbi.nlm.nih.gov/pubmed/37616260
http://dx.doi.org/10.1371/journal.pone.0289046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449137/
https://www.ncbi.nlm.nih.gov/pubmed/37616260
http://dx.doi.org/10.1371/journal.pone.0289046

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