Cargando…

Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage

BACKGROUND: Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite whose levels are significantly modified following an acute kidney injury (AKI) and to analyze whether this agent could offer cardiac protectio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bigelman, Einat, Pasmanik-Chor, Metsada, Dassa, Bareket, Itkin, Maxim, Malitsky, Sergey, Dorot, Orly, Pichinuk, Edward, Kleinberg, Yuval, Keren, Gad, Entin-Meer, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449225/ https://www.ncbi.nlm.nih.gov/pubmed/37616231 http://dx.doi.org/10.1371/journal.pone.0275550

Ejemplares similares

Correction: Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody
por: Cohen, Lena, et al.
Publicado: (2020)

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells
por: Morein, Dina, et al.
Publicado: (2021)

TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages
por: Entin-Meer, Michal, et al.
Publicado: (2017)

Pathological presentation of cardiac mitochondria in a rat model for chronic kidney disease
por: Bigelman, Einat, et al.
Publicado: (2018)

Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody
por: Cohen, Lena, et al.
Publicado: (2020)

Drosophila melanogaster Mutated in its GBA1b Ortholog Recapitulates Neuronopathic Gaucher Disease
por: Cabasso, Or, et al.
Publicado: (2019)

Lower levels of the neuroprotective tryptophan metabolite, kynurenic acid, in users of estrogen contraceptives
por: Bjørke-Monsen, Anne-Lise, et al.
Publicado: (2023)

De novo transcriptome characterization of Iris atropurpurea (the Royal Iris) and phylogenetic analysis of MADS-box and R2R3-MYB gene families
por: Bar-Lev, Yamit, et al.
Publicado: (2021)

Author Correction: De novo transcriptome characterization of Iris atropurpurea (the Royal Iris) and phylogenetic analysis of MADS-box and R2R3-MYB gene families
por: Bar-Lev, Yamit, et al.
Publicado: (2021)

Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions
por: Wirthgen, Elisa, et al.
Publicado: (2018)

Possibility of Amino Acid Treatment to Prevent the Psychiatric Disorders via Modulation of the Production of Tryptophan Metabolite Kynurenic Acid
por: Fukuwatari, Tsutomu
Publicado: (2020)

Hierarchical Partitioning of Metazoan Protein Conservation Profiles Provides New Functional Insights
por: Witztum, Jonathan, et al.
Publicado: (2014)

The Immunomodulator 1-Methyltryptophan Drives Tryptophan Catabolism Toward the Kynurenic Acid Branch
por: Wirthgen, Elisa, et al.
Publicado: (2020)

Simulation and visualization of multiple KEGG pathways using BioNSi
por: Yeheskel, Adva, et al.
Publicado: (2018)

Tryptophan, Kynurenine and Kynurenic Acid Concentrations in Milk and Serum of Dairy Cows with Prototheca Mastitis
por: Bochniarz, Mariola, et al.
Publicado: (2021)

Effects of IKAP/hELP1 Deficiency on Gene Expression in Differentiating Neuroblastoma Cells: Implications for Familial Dysautonomia
por: Cohen-Kupiec, Rachel, et al.
Publicado: (2011)

HeatMapViewer: interactive display of 2D data in biology
por: Yachdav, Guy, et al.
Publicado: (2014)

Effects of Tranilast on the Urinary Excretion of Kynurenic and Quinolinic Acid Under Conditions of L Tryptophan Loading
por: Noakes, Rowland R.
Publicado: (2013)

Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
por: Saran, Tomasz, et al.
Publicado: (2021)

Systems Analysis of Insulin and IGF1 Receptors Networks in Breast Cancer Cells Identifies Commonalities and Divergences in Expression Patterns
por: Sarfstein, Rive, et al.
Publicado: (2020)

On the Origins of Enzymes: Phosphate-Binding Polypeptides Mediate Phosphoryl Transfer to Synthesize Adenosine Triphosphate
por: Vyas, Pratik, et al.
Publicado: (2023)

R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers
por: Boldes, Tomer, et al.
Publicado: (2020)

Autophagy is induced and modulated by cholesterol depletion through transcription of autophagy-related genes and attenuation of flux
por: Shapira, Keren E., et al.
Publicado: (2021)

Tryptophan and Kynurenic Acid May Produce an Amplified Effect in Central Fatigue Induced by Chronic Sleep Disorder
por: Yamashita, Masatoshi, et al.
Publicado: (2014)

eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling
por: Attar-Schneider, Oshrat, et al.
Publicado: (2015)

Genome-Wide Analyses Identify Filamin-A As a Novel Downstream Target for Insulin and IGF1 Action
por: Aizen, Daniel, et al.
Publicado: (2018)

Differential gene expression and transport functionality in the bundle sheath versus mesophyll – a potential role in leaf mineral homeostasis
por: Wigoda, Noa, et al.
Publicado: (2017)

A Tumor Microenvironment-Driven Network Regulated by STAT3 and p65 Negatively Controls the Enrichment of Cancer Stem Cells in Human HR+/HER2− Breast Cancer
por: Ben-Yaakov, Hagar, et al.
Publicado: (2023)

Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns
por: Shahal, Tamar, et al.
Publicado: (2022)

Antiviral activity of glucosylceramide synthase inhibitors in alphavirus infection of the central nervous system
por: Avraham, Roy, et al.
Publicado: (2023)

Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment
por: Zitman-Gal, Tali, et al.
Publicado: (2014)

Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro
por: Sintov, Elad, et al.
Publicado: (2015)

Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy
por: Menachem, Assaf, et al.
Publicado: (2016)

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients
por: Sinai-Livne, Tali, et al.
Publicado: (2020)

The Uncovered Function of the Drosophila GBA1a-Encoded Protein
por: Cabasso, Or, et al.
Publicado: (2021)

MicroRNA 132-3p Is Upregulated in Laron Syndrome Patients and Controls Longevity Gene Expression
por: Yaron-Saminsky, Danielle, et al.
Publicado: (2021)

Serine peptidases and increased amounts of soluble proteins contribute to heat priming of the plant pathogenic fungus Botrytis cinerea
por: Zhang, Mingzhe, et al.
Publicado: (2023)

The Transient Receptor Potential Vanilloid 2 Cation Channel Is Abundant in Macrophages Accumulating at the Peri-Infarct Zone and May Enhance Their Migration Capacity towards Injured Cardiomyocytes following Myocardial Infarction
por: Entin-Meer, Michal, et al.
Publicado: (2014)

Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells
por: Rubinstein-Achiasaf, Linor, et al.
Publicado: (2021)

Author Correction: Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing
por: Reichman, Hadar, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_80l23th2opkcahle61lmd500og