Exosomal miR-663b from “M1” macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis

Background: Inflammatory mediators from macrophages are proven to be involved in pulmonary vascular remodeling in pulmonary hypertension (PH). Here, this study intends to explore the mechanism of “M1” macrophage-derived exosomal miR-663b in pulmonary artery smooth muscle cells (PASMCs) dysfunctions...

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Detalles Bibliográficos
Autores principales: Ma, Honghong, Yu, Yang, Mo, Lirong, Chen, Qian, Dong, Hui, Xu, Yan, Zhuan, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449306/
https://www.ncbi.nlm.nih.gov/pubmed/37142272
http://dx.doi.org/10.18632/aging.204690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449306/
https://www.ncbi.nlm.nih.gov/pubmed/37142272
http://dx.doi.org/10.18632/aging.204690

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