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Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials—the trialists’ view

Extracorporeal cardiopulmonary resuscitation is a promising treatment for refractory out-of-hospital cardiac arrest. Three recent randomized trials (ARREST trial, Prague OHCA study, and INCEPTION trial) that addressed the clinical benefit of extracorporeal cardiopulmonary resuscitation in out-of-hos...

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Autores principales: Ubben, Johannes F H, Heuts, Samuel, Delnoij, Thijs S R, Suverein, Martje M, van de Koolwijk, Anina F, van der Horst, Iwan C C, Maessen, Jos G, Bartos, Jason, Kavalkova, Petra, Rob, Daniel, Yannopoulos, Demetris, Bělohlávek, Jan, Lorusso, Roberto, van de Poll, Marcel C G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449372/
https://www.ncbi.nlm.nih.gov/pubmed/37480551
http://dx.doi.org/10.1093/ehjacc/zuad071
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author Ubben, Johannes F H
Heuts, Samuel
Delnoij, Thijs S R
Suverein, Martje M
van de Koolwijk, Anina F
van der Horst, Iwan C C
Maessen, Jos G
Bartos, Jason
Kavalkova, Petra
Rob, Daniel
Yannopoulos, Demetris
Bělohlávek, Jan
Lorusso, Roberto
van de Poll, Marcel C G
author_facet Ubben, Johannes F H
Heuts, Samuel
Delnoij, Thijs S R
Suverein, Martje M
van de Koolwijk, Anina F
van der Horst, Iwan C C
Maessen, Jos G
Bartos, Jason
Kavalkova, Petra
Rob, Daniel
Yannopoulos, Demetris
Bělohlávek, Jan
Lorusso, Roberto
van de Poll, Marcel C G
author_sort Ubben, Johannes F H
collection PubMed
description Extracorporeal cardiopulmonary resuscitation is a promising treatment for refractory out-of-hospital cardiac arrest. Three recent randomized trials (ARREST trial, Prague OHCA study, and INCEPTION trial) that addressed the clinical benefit of extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest yielded seemingly diverging results. The evidence for extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest, derived from three recent randomized controlled trials, is not contradictory but rather complementary. Excellent results can be achieved with a very high level of dedication, provided that strict selection criteria are applied. However, pragmatic implementation of extracorporeal cardiopulmonary resuscitation does not necessarily lead to improved outcome of refractory out-of-hospital cardiac arrest. Centres that are performing extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest or aspire to do so should critically evaluate whether they are able to meet the pre-requisites that are needed to conduct an effective extracorporeal cardiopulmonary resuscitation programme.
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spelling pubmed-104493722023-08-25 Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials—the trialists’ view Ubben, Johannes F H Heuts, Samuel Delnoij, Thijs S R Suverein, Martje M van de Koolwijk, Anina F van der Horst, Iwan C C Maessen, Jos G Bartos, Jason Kavalkova, Petra Rob, Daniel Yannopoulos, Demetris Bělohlávek, Jan Lorusso, Roberto van de Poll, Marcel C G Eur Heart J Acute Cardiovasc Care Review Extracorporeal cardiopulmonary resuscitation is a promising treatment for refractory out-of-hospital cardiac arrest. Three recent randomized trials (ARREST trial, Prague OHCA study, and INCEPTION trial) that addressed the clinical benefit of extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest yielded seemingly diverging results. The evidence for extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest, derived from three recent randomized controlled trials, is not contradictory but rather complementary. Excellent results can be achieved with a very high level of dedication, provided that strict selection criteria are applied. However, pragmatic implementation of extracorporeal cardiopulmonary resuscitation does not necessarily lead to improved outcome of refractory out-of-hospital cardiac arrest. Centres that are performing extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest or aspire to do so should critically evaluate whether they are able to meet the pre-requisites that are needed to conduct an effective extracorporeal cardiopulmonary resuscitation programme. Oxford University Press 2023-07-22 /pmc/articles/PMC10449372/ /pubmed/37480551 http://dx.doi.org/10.1093/ehjacc/zuad071 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review
Ubben, Johannes F H
Heuts, Samuel
Delnoij, Thijs S R
Suverein, Martje M
van de Koolwijk, Anina F
van der Horst, Iwan C C
Maessen, Jos G
Bartos, Jason
Kavalkova, Petra
Rob, Daniel
Yannopoulos, Demetris
Bělohlávek, Jan
Lorusso, Roberto
van de Poll, Marcel C G
Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials—the trialists’ view
title Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials—the trialists’ view
title_full Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials—the trialists’ view
title_fullStr Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials—the trialists’ view
title_full_unstemmed Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials—the trialists’ view
title_short Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials—the trialists’ view
title_sort extracorporeal cardiopulmonary resuscitation for refractory ohca: lessons from three randomized controlled trials—the trialists’ view
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449372/
https://www.ncbi.nlm.nih.gov/pubmed/37480551
http://dx.doi.org/10.1093/ehjacc/zuad071
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