Adapting antibacterial display to identify serum-active macrocyclic peptide antibiotics

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The lack of available treatments for many antimicrobial-resistant infections highlights the critical need for antibiotic discovery innovation. Peptides are an underappreciated antibiotic scaffold because they often suffer from proteolytic instability and toxicity toward human cells, making in vivo u...

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Detalles Bibliográficos
Autores principales: Randall, Justin R, Groover, Kyra E, O'Donnell, Angela C, Garza, Joseph M, Cole, T Jeffrey, Davies, Bryan W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449418/
https://www.ncbi.nlm.nih.gov/pubmed/37637199
http://dx.doi.org/10.1093/pnasnexus/pgad270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449418/
https://www.ncbi.nlm.nih.gov/pubmed/37637199
http://dx.doi.org/10.1093/pnasnexus/pgad270

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