High-throughput thermal denaturation of tryptophanyl-tRNA synthetase combinatorial mutants reveals high-order energetic coupling determinants of conformational stability

Landscape descriptions provide a framework for identifying functionally significant dynamic linkages in proteins but cannot supply details. Rate measurements of combinatorial mutations can implicate dynamic linkages in catalysis. A major difficulty is filtering dynamic linkages from the vastly more...

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Detalles Bibliográficos
Autores principales: Weinreb, Violetta, Weinreb, Gabriel, Carter, Charles W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Crystallographic Association 2023
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449480/
https://www.ncbi.nlm.nih.gov/pubmed/37637481
http://dx.doi.org/10.1063/4.0000182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449480/
https://www.ncbi.nlm.nih.gov/pubmed/37637481
http://dx.doi.org/10.1063/4.0000182

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