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High-throughput thermal denaturation of tryptophanyl-tRNA synthetase combinatorial mutants reveals high-order energetic coupling determinants of conformational stability

Landscape descriptions provide a framework for identifying functionally significant dynamic linkages in proteins but cannot supply details. Rate measurements of combinatorial mutations can implicate dynamic linkages in catalysis. A major difficulty is filtering dynamic linkages from the vastly more...

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Detalles Bibliográficos
Autores principales:	Weinreb, Violetta, Weinreb, Gabriel, Carter, Charles W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Crystallographic Association 2023
Materias:	ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449480/ https://www.ncbi.nlm.nih.gov/pubmed/37637481 http://dx.doi.org/10.1063/4.0000182

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