Single-Nucleus Profiling Identifies Accelerated Oligodendrocyte Precursor Cell Senescence in a Mouse Model of Down Syndrome

Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with lifelong cognitive deficits. However, the mechanisms by which triplication of chromosome 21 genes drive neuroinflammation and cognitive dysfunction are poorly understood. Here, using the Ts65Dn mouse mod...

Descripción completa

Detalles Bibliográficos
Autores principales: Rusu, Bianca, Kukreja, Bharti, Wu, Taiyi, Dan, Sophie J., Feng, Min Yi, Kalish, Brian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449487/
https://www.ncbi.nlm.nih.gov/pubmed/37491366
http://dx.doi.org/10.1523/ENEURO.0147-23.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449487/
https://www.ncbi.nlm.nih.gov/pubmed/37491366
http://dx.doi.org/10.1523/ENEURO.0147-23.2023

Ejemplares similares