Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment

Amyloid precursor protein (APP) internalization via clathrin-/dynamin-mediated endocytosis (CME) mediated by its YENPTY motif into endosomes containing β-secretase is proposed to be critical for amyloid-beta (Aβ) production. Here, we show that somatodendritic APP internalization in primary rodent ne...

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Detalles Bibliográficos
Autores principales: Aow, Jonathan, Huang, Tzu-Rung, Goh, Yeek Teck, Sun, Alfred Xuyang, Thinakaran, Gopal, Koo, Edward H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449584/
https://www.ncbi.nlm.nih.gov/pubmed/37450368
http://dx.doi.org/10.1016/j.celrep.2023.112774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449584/
https://www.ncbi.nlm.nih.gov/pubmed/37450368
http://dx.doi.org/10.1016/j.celrep.2023.112774

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