Signal peptide mimicry primes Sec61 for client-selective inhibition

Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy, but attempts to target essential protein biogenesis factors have been hampered by excessive toxicity. Here we describe KZR-8445, a cyclic depsipeptide that targets the Sec61 translocon and selectively disru...

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מידע ביבליוגרפי
Autores principales: Rehan, Shahid, Tranter, Dale, Sharp, Phillip P., Craven, Gregory B., Lowe, Eric, Anderl, Janet L., Muchamuel, Tony, Abrishami, Vahid, Kuivanen, Suvi, Wenzell, Nicole A., Jennings, Andy, Kalyanaraman, Chakrapani, Strandin, Tomas, Javanainen, Matti, Vapalahti, Olli, Jacobson, Matthew P., McMinn, Dustin, Kirk, Christopher J., Huiskonen, Juha T., Taunton, Jack, Paavilainen, Ville O.
פורמט: Online Artículo Texto
שפה:English
יצא לאור: Nature Publishing Group US 2023
נושאים:
Article
גישה מקוונת:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449633/
https://www.ncbi.nlm.nih.gov/pubmed/37169961
http://dx.doi.org/10.1038/s41589-023-01326-1

אינטרנט

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449633/
https://www.ncbi.nlm.nih.gov/pubmed/37169961
http://dx.doi.org/10.1038/s41589-023-01326-1

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