Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model

INTRODUCTION: Huntington’s disease (HD) is caused by CAG trinucleotide repeats in the HTT gene. Selective neurodegeneration in the striatum is prominent in HD, despite widespread expression of mutant HTT (mHTT). Ras homolog enriched in the striatum (Rhes) is a GTP-binding protein enriched in the str...

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Yongcheng, Tang, Beisha, Li, Xiao-Jiang, Li, Shihua, Liu, Qiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449645/
https://www.ncbi.nlm.nih.gov/pubmed/37637962
http://dx.doi.org/10.3389/fnagi.2023.1237018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449645/
https://www.ncbi.nlm.nih.gov/pubmed/37637962
http://dx.doi.org/10.3389/fnagi.2023.1237018

Ejemplares similares