Cargando…

Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model

INTRODUCTION: Huntington’s disease (HD) is caused by CAG trinucleotide repeats in the HTT gene. Selective neurodegeneration in the striatum is prominent in HD, despite widespread expression of mutant HTT (mHTT). Ras homolog enriched in the striatum (Rhes) is a GTP-binding protein enriched in the str...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Yongcheng, Tang, Beisha, Li, Xiao-Jiang, Li, Shihua, Liu, Qiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449645/ https://www.ncbi.nlm.nih.gov/pubmed/37637962 http://dx.doi.org/10.3389/fnagi.2023.1237018

Ejemplares similares

Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain
por: Ramírez-Jarquín, Uri Nimrod, et al.
Publicado: (2022)

Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
por: Yang, Huiming, et al.
Publicado: (2020)

Rhes, a striatal-enriched protein, promotes mitophagy via Nix
por: Sharma, Manish, et al.
Publicado: (2019)

Striatal Induction and Spread of the Huntington’s Disease Protein: A Novel Rhes Route
por: Subramaniam, Srinivasa
Publicado: (2022)

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
por: Yang, Huiming, et al.
Publicado: (2020)

Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington’s Disease
por: Osmand, Alexander P., et al.
Publicado: (2016)

The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses
por: Napolitano, Francesco, et al.
Publicado: (2019)

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease
por: Zhou, Ya, et al.
Publicado: (2021)

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin
por: Galvan, Laurie, et al.
Publicado: (2018)

Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons
por: Trushina, Eugenia, et al.
Publicado: (2009)

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models
por: Franich, Nicholas R., et al.
Publicado: (2018)

Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response
por: Chen, Xingxing, et al.
Publicado: (2020)

Grb2 Is Regulated by Foxd3 and Has Roles in Preventing Accumulation and Aggregation of Mutant Huntingtin
por: Baksi, Shounak, et al.
Publicado: (2013)

Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion
por: Ghiglieri, Veronica, et al.
Publicado: (2015)

Global Rhes knockout in the Q175 Huntington’s disease mouse model
por: Heikkinen, Taneli, et al.
Publicado: (2021)

Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
por: Subramaniam, Srinivasa, et al.
Publicado: (2011)

Tissue Transglutaminase Does Not Contribute to the Formation of Mutant Huntingtin Aggregates
por: Chun, Wanjoo, et al.
Publicado: (2001)

Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin
por: Tan, Z, et al.
Publicado: (2015)

GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin
por: Ahat, Erpan, et al.
Publicado: (2022)

Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice
por: Wang, Chuan-En, et al.
Publicado: (2010)

N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice
por: Gu, Xiaofeng, et al.
Publicado: (2015)

Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation
por: Teuling, Eva, et al.
Publicado: (2011)

MicroRNA-101 inhibits the expression of Rhes, a striatal-enriched small G-protein, at the post-transcriptional level in vitro
por: Mizuno, Hideya, et al.
Publicado: (2018)

PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model
por: Carnemolla, Alisia, et al.
Publicado: (2017)

Mutant huntingtin enhances activation of dendritic Kv4 K(+) channels in striatal spiny projection neurons
por: Carrillo-Reid, Luis, et al.
Publicado: (2019)

Human-to-mouse prion-like propagation of mutant huntingtin protein
por: Jeon, Iksoo, et al.
Publicado: (2016)

The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain
por: Datson, Nicole A., et al.
Publicado: (2017)

RNAi Screening in Drosophila Cells Identifies New Modifiers of Mutant Huntingtin Aggregation
por: Doumanis, Joanna, et al.
Publicado: (2009)

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT
por: Bauer, Peter O, et al.
Publicado: (2012)

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
por: Herrmann, Frank, et al.
Publicado: (2021)

Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila
por: Roth, Jonathan R., et al.
Publicado: (2023)

Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates
por: Bae, Donghwi, et al.
Publicado: (2022)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
por: Liang, Qiuli, et al.
Publicado: (2011)

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation
por: O’Rourke, Jacqueline Gire, et al.
Publicado: (2013)

Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin
por: Wang, Chuan-En, et al.
Publicado: (2008)

Exploration of sex differences in Rhes effects in dopamine mediated behaviors
por: Quintero, Gabriel C, et al.
Publicado: (2011)

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
por: Yao, Yuwei, et al.
Publicado: (2015)

Modulation of Mutant Huntingtin N-Terminal Cleavage and Its Effect on Aggregation and Cell Death
por: Juenemann, Katrin, et al.
Publicado: (2010)

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses
por: Donnelly, Kirby M, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7ij0d144jntka2od1e8v72h9ml