Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis

Leveraging genome-wide association statistics generated from a large study of amyotrophic lateral sclerosis (ALS; 29,612 cases and 122,656 controls) and UK Biobank (UKB; 4,024 phenotypes, up to 361,194 participants), we conducted a phenome-wide analysis of ALS genetic liability and identified 46 gen...

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Detalles Bibliográficos
Autores principales: D’Antona, Salvatore, Pathak, Gita A., Koller, Dora, Porro, Danilo, Cava, Claudia, Polimanti, Renato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449723/
https://www.ncbi.nlm.nih.gov/pubmed/36773064
http://dx.doi.org/10.1007/s00439-023-02525-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449723/
https://www.ncbi.nlm.nih.gov/pubmed/36773064
http://dx.doi.org/10.1007/s00439-023-02525-5

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