Predicting [(177)Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [(68)Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling

BACKGROUND: Prediction of [(177)Lu]Lu-HA-DOTATATE kidney and tumor uptake based on diagnostic [(68)Ga]Ga-HA-DOTATATE imaging would be a crucial step for precision dosing of [(177)Lu]Lu-HA-DOTATATE. In this study, the population pharmacokinetic (PK) differences between [(177)Lu]Lu-HA-DOTATATE and [(6...

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Detalles Bibliográficos
Autores principales: Siebinga, Hinke, de Wit-van der Veen, Berlinda J., Beijnen, Jos H., Stokkel, Marcel P. M., Dorlo, Thomas P. C., Huitema, Alwin D. R., Hendrikx, Jeroen J. M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449733/
https://www.ncbi.nlm.nih.gov/pubmed/37615812
http://dx.doi.org/10.1186/s40658-023-00565-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449733/
https://www.ncbi.nlm.nih.gov/pubmed/37615812
http://dx.doi.org/10.1186/s40658-023-00565-4

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