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Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and neurodegeneration. The retina is an extension of the central nervous system within the eye, sharing many structural similar...

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Detalles Bibliográficos
Autores principales: Lavekar, Sailee S., Harkin, Jade, Hernandez, Melody, Gomes, Cátia, Patil, Shruti, Huang, Kang-Chieh, Puntambekar, Shweta S., Lamb, Bruce T., Meyer, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449801/
https://www.ncbi.nlm.nih.gov/pubmed/37620502
http://dx.doi.org/10.1038/s41598-023-40382-4