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Downregulation of chemokine receptor 9 facilitates CD4(+)CD8αα(+) intraepithelial lymphocyte development
Intestinal intraepithelial lymphocytes (IELs) reside in the gut epithelial layer, where they help in maintaining intestinal homeostasis. Peripheral CD4(+) T cells can develop into CD4(+)CD8αα(+) IELs upon arrival at the gut epithelium via the lamina propria (LP). Although this specific differentiati...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449822/ https://www.ncbi.nlm.nih.gov/pubmed/37620389 http://dx.doi.org/10.1038/s41467-023-40950-2 |